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With incredible optimization, I believe you can go above 3k hp. regen. per second. But even if you get this high, you will remain potentially vulnerable to huge bursts of damage and have undesirably low resistances.
If you want a truly tanky toon, you should not aim for this Hp-regen gimmick and go for a classic Guardian. Have maxed recharge for permanent Colossus Form, Quick Recovery, Rally and Briar Ward for near 100% damage absorption, reflection and block chance.You could get well above 15k HP this way, and be completely safe from one-shot attacks.