Just regged to say this.

I think bleed build might work rather okay (just soft tested it with lvl 40). Bone Charmer is the way (probably works for Rogue too, not sure). Either way, you can get -81% to enemy res vs bleeding. Im not sure how it scales with some extra levels, but probably might be enough to make about everything bleed.

Anyway, I think Death Chill aura + upgraded Study Prey might be able to get enemy bleed res to nicely negative department.

Also did small test with Spellbreaker (Warfare and Spirit) and +1 skill gives jump to 89%, so.. I guess +3 skills might tip it over 100%?

Poison is sadly I think not possible. :/ Nature gives some negative res to that, but its only 39% and probably wont go that far even with plus skills.