I just tried it in Titan Quest Anniversary Edition and it's working. I've made an accomplished hero and a normal character to test it and both are working flawlessly. I noticed a framerate drop when opening the skill menu, however, when I was using the default UI (which screwed around with the custom UI anyways) that I didn't receive when using the original Titan Quest UI. Maybe try changing them? But currently I am playing around with everything and it's working so far.