hello mountainblade welcome to the new forum.. i see you're playing corsair.. rogue is actually my favorite mastery but oddly enough, defense is my least favorite :/ .. but there's no denying the survivability defense gives.. the safe traditional way is to get calculated strike for LMB and 1/max/1max envenom line.. from defense, all the tanky skills and shield attack skills.. you can still get lethal strike but if you value ease of use, maybe just shield charge as RMB. i actually would not advice spear but rather, just fast attacking weapons.. the reason being, faster attacks mean more shield attack procs.. but if you can still get max attack speed or close to that with a spear, then why not? spear benefits greatly from blade honing and you deal more damage with lethal strike if using a spear rather than a sword. one option is to use throwing knives or bow on secondary to hit with lethal strike however blade honing doesn't work with bows so you have to cast it again when switching back to main weapon.. throwing knives work with blade honing and lethal strike but deals less damage..i like having my dex to at least 400+ endgame, str much higher.. i don't know the new mechanics now on pierce damage or if it changed at all however, i can guarantee its still a safe route
But unfortunately for you, you posted on Christmas season.. and special occasions deserve special builds.. so you have no choice but to take less popular but fun builds:
1) set traps, throw poison gas bomb, then go charging in with shield charge
2) max throwing knives, flurry of knives, the whole envenom line, and anatomy.. yep, be a caster then when they get confused, go charging in with shield charge
3) just throwing knives with no shield charge, stats still str/dex but you have to have flat physical damage from items to boost throwing knives.. tops might be 2 mark of ares and a pendant of immortal rage
4) throwing knives with just enough str to wear
Moon Disc.. the rest dex and int.. get flat elemental damage from items like Archimedes cogwheel and/or occult ring with Eitr.. i don't have a link but Eitr is a monster charm from act 5 that gives flat elemental damage.. Moon Disc will boost that.. max armor handling for more item choices
you can choose 1 or make your own ridiculous build.. lol probably not the welcome you're expecting